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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL221674
Molecular formula	C32H36N6O3
IUPAC name	2-amino-N-[(1R)-1-[5-benzyl-4-[(3,5-dimethoxyphenyl)methyl]-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2-methylpropanamide
Molecular weight	552.679
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	3.9
Synonyms	BDBM50208706 SCHEMBL3634538 (R)-N-(1-(4-(3,5-dimethoxybenzyl)-5-benzyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide
Inchi Key	ACNDZZGAEOBNLV-MUUNZHRXSA-N
Inchi ID	InChI=1S/C32H36N6O3/c1-32(2,33)31(39)35-28(17-23-19-34-27-13-9-8-12-26(23)27)30-37-36-29(16-21-10-6-5-7-11-21)38(30)20-22-14-24(40-3)18-25(15-22)41-4/h5-15,18-19,28,34H,16-17,20,33H2,1-4H3,(H,35,39)/t28-/m1/s1
PubChem CID	16203930
ChEMBL	CHEMBL221674
IUPHAR	N/A
BindingDB	50208706
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	29.0 %	PMID17375904	ChEMBL
IC50	110.0 nM	PMID17375904	BindingDB,ChEMBL

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