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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 1
Species	Mus musculus (Mouse)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
UniProt	Q76JU9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5411
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	TUG-770
Molecular formula	C19H14FNO2
IUPAC name	3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid
Molecular weight	307.324
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	D0S0QY SCHEMBL12983515 AB0095804 FT-0722551 TUG770 3-(4-{2-[2-(cyanomethyl)phenyl]ethynyl}-2-fluorophenyl)propanoic acid BCP07966 CHEMBL2386353 KB-145939 DA-45349 TUG 770 1402601-82-4 AKOS030235391 GTPL6483 W-6124 3-(4-{[2-(Cyanomethyl)phenyl]ethynyl}-2-fluorophenyl)propanoic acid BDBM50434295 CS-1524 QC-4555 DTXSID90735197 3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid BC600433 HY-15697 ZINC95930190 4CA-1291 [ Show all ]
Inchi Key	KIZUBVPJNPVIIN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
PubChem CID	66553168
ChEMBL	CHEMBL2386353
IUPHAR	6483
BindingDB	50434295
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	147.91 nM	PMID23687558	ChEMBL
EC50	148.0 nM	PMID23687558	BindingDB

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