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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2C adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P22086
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL314
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Metrenperone
Molecular formula	C24H26FN3O2
IUPAC name	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2,7-dimethylpyrido[1,2-a]pyrimidin-4-one
Molecular weight	407.489
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.7
Synonyms	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2,7-dimethylpyrido[1,2-a]pyrimidin-4-one CHEMBL2104852 R-50970 DTXSID20230867 Metrenperonum UNII-W1O4FV809G 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one BDBM82382 Metrenperona R 50 970 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-2,7-dimethyl- D04EYR Metrenperone (USAN/INN) SCHEMBL2109868 3-(2-(4-(4-Fluorobenzoyl)-1-piperidyl)ethyl)-2,7-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one AC1L2H8G EINECS 279-678-7 Metrenperonum [INN-Latin] W1O4FV809G 3-[2-[4-(4-Fluorobenzoyl)-1-piperidyl]ethyl]-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one CAS_72005 Metrenperona [INN-Spanish] R 50970 81043-56-3 D05015 Metrenperone [USAN:INN:BAN] Sinomedol 3-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)-2,7-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one AC1Q4NI9 FT-0672391 NSC_72005 ZINC537997 [ Show all ]
Inchi Key	AXQRPYKSPHUOGZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3
PubChem CID	72005
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82382
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.5 nM	PMID2876905	BindingDB
Ki	2.8 nM	PMID2876905	BindingDB
Ki	10.0 nM	PMID2876905	BindingDB

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