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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	CX3C chemokine receptor 1
Species	Homo sapiens (Human)
Gene	CX3CR1
Synonym	Beta chemokine receptor-like 1 Rbs11 GPR13 G-protein coupled receptor 13 Fractalkine receptor CX3CR1 CMKDR1 CMKBRL1 CMK-BRL1 CMK-BRL-1 chemokine (C-X3-C motif) receptor 1 CCRL1 C-X3-C CKR-1 V28 [ Show all ]
Disease	N/A
Length	355
Amino acid sequence	MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
UniProt	P49238
Protein Data Bank	N/A
GPCR-HGmod model	P49238
3D structure model	This predicted structure model is from GPCR-EXP P49238.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4843
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL10309
Molecular formula	C23H25BrN2O2
IUPAC name	3-[1-[(4-bromophenyl)methyl]piperidin-4-yl]-3-phenylpiperidine-2,6-dione
Molecular weight	441.369
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.8
Synonyms	(+/-)-1''-(4-bromobenzyl)-3-phenyl-3,4''-bipiperidine-2,6-dione (-)-1''-(4-bromobenzyl)-3-phenyl-3,4''-bipiperidine-2,6-dione BDBM50018553 (+)-1''-(4-bromobenzyl)-3-phenyl-3,4''-bipiperidine-2,6-dione SCHEMBL13962970 1''-(4-Bromo-benzyl)-3-phenyl-[3,4'']bipiperidinyl-2,6-dione [ Show all ]
Inchi Key	KIBLABCMQPRMIQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25BrN2O2/c24-20-8-6-17(7-9-20)16-26-14-11-19(12-15-26)23(18-4-2-1-3-5-18)13-10-21(27)25-22(23)28/h1-9,19H,10-16H2,(H,25,27,28)
PubChem CID	14479864
ChEMBL	CHEMBL10309
IUPHAR	N/A
BindingDB	50018553
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>25.0 %	PMID18922694	ChEMBL

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