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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000147498
Molecular formula	C22H20ClN3OS2
IUPAC name	3-amino-4-(4-chlorophenyl)-N,N-diethyl-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide
Molecular weight	441.992
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	6.2
Synonyms	MolPort-000-701-624 AC1LR0KQ CHEMBL1488995 STK546025 MCULE-6617781972 3-amino-4-(4-chlorophenyl)-N,N-diethyl-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide RSC005370 AKOS003680476 EU-0081186 ZINC1295962 3-Amino-4-(4-chloro-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid diethylamide MLS000555981 499119-74-3 HMS2348B21 3-amino-4-(4-chlorophenyl)-N,N-diethyl-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide [ Show all ]
Inchi Key	KGKFCPHSLHZTNV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20ClN3OS2/c1-3-26(4-2)22(27)20-19(24)18-15(13-7-9-14(23)10-8-13)12-16(25-21(18)29-20)17-6-5-11-28-17/h5-12H,3-4,24H2,1-2H3
PubChem CID	1415522
ChEMBL	CHEMBL1488995
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5011.9 nM	PubChem BioAssay data set	ChEMBL

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