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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesRattus norvegicus (Rat)
GeneChrm5
Synonymcholinergic receptor
cholinergic receptor, muscarinic 5
M5 receptor
M5R
DiseaseN/A for non-human GPCRs
Length531
Amino acid sequenceMEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08911
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL277
IUPHAR17
DrugBankN/A

Ligand

NameCHEMBL414182
Molecular formulaC18H22N2
IUPAC nameN,N-dimethyl-1-(4-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methanamine
Molecular weight266.388
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP2.9
Synonyms1,2,3,4-tetrahydro-1-dimethylaminomethyl-4-phenylisoquinoline
KEUSBNOLUMCSQJ-UHFFFAOYSA-N
BDBM50028306
cis-Dimethyl-(4-phenyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-amine
Inchi KeyKEUSBNOLUMCSQJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H22N2/c1-20(2)13-18-16-11-7-6-10-15(16)17(12-19-18)14-8-4-3-5-9-14/h3-11,17-19H,12-13H2,1-2H3
PubChem CID13457439
ChEMBLCHEMBL414182
IUPHARN/A
BindingDB50028306
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC504000.0 nMPMID6747997BindingDB,ChEMBL

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