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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Somatostatin receptor type 3
Species	Homo sapiens (Human)
Gene	SSTR3
Synonym	SSR-28 SS3R SS3-R SS-3-R SRIF1C somatostatin receptor 28 SST3 receptor [ Show all ]
Disease	N/A
Length	418
Amino acid sequence	MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
UniProt	P32745
Protein Data Bank	N/A
GPCR-HGmod model	P32745
3D structure model	This predicted structure model is from GPCR-EXP P32745.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2028
IUPHAR	357
DrugBank	BE0003529

Ligand

Name	CHEMBL3287613
Molecular formula	C22H24FN3O
IUPAC name	4-fluoro-N-[(1R,2S)-2-(1H-indol-3-ylmethylamino)cyclohexyl]benzamide
Molecular weight	365.452
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	3.8
Synonyms	BDBM50021063
Inchi Key	KCYOCCOLGUUYQZ-LEWJYISDSA-N
Inchi ID	InChI=1S/C22H24FN3O/c23-17-11-9-15(10-12-17)22(27)26-21-8-4-3-7-20(21)25-14-16-13-24-19-6-2-1-5-18(16)19/h1-2,5-6,9-13,20-21,24-25H,3-4,7-8,14H2,(H,26,27)/t20-,21+/m0/s1
PubChem CID	90644981
ChEMBL	CHEMBL3287613
IUPHAR	N/A
BindingDB	50021063
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	97.0 %	PMID24944745	ChEMBL
EC50	2.88 nM	PMID24944745	ChEMBL
EC50	2.9 nM	PMID24944745	BindingDB
Inhibition	-14.0 %	PMID24944745	ChEMBL
Ki	3.78 nM	PMID24944745	ChEMBL
Ki	3.8 nM	PMID24944745	BindingDB

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