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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1778241
Molecular formula	C21H24ClN3O4S
IUPAC name	(1S,5S)-3-[6-(2-chlorophenoxy)-5-methylpyrimidin-4-yl]oxy-8-cyclopropylsulfonyl-8-azabicyclo[3.2.1]octane
Molecular weight	449.95
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.4
Synonyms	BDBM50344504 (1S,5S)-3-(6-(2-chlorophenoxy)-5-methylpyrimidin-4-yloxy)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octane
Inchi Key	KCQDKJGXIVQJDK-GJZGRUSLSA-N
Inchi ID	InChI=1S/C21H24ClN3O4S/c1-13-20(23-12-24-21(13)29-19-5-3-2-4-18(19)22)28-16-10-14-6-7-15(11-16)25(14)30(26,27)17-8-9-17/h2-5,12,14-17H,6-11H2,1H3/t14-,15-/m0/s1
PubChem CID	54583666
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50344504
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	44.0 nM	PMID21536438	BindingDB

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