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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	SCHEMBL4802558
Molecular formula	C24H33N3O4S
IUPAC name	N-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-2,2-dimethyl-3,4-dihydrochromene-6-sulfonamide
Molecular weight	459.605
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.7
Synonyms	CHEMBL2364453
Inchi Key	AXCLMWWQFJTKNU-CALCHBBNSA-N
Inchi ID	InChI=1S/C24H33N3O4S/c1-16-14-27(15-17(2)25-16)19-6-8-23(30-5)21(13-19)26-32(28,29)20-7-9-22-18(12-20)10-11-24(3,4)31-22/h6-9,12-13,16-17,25-26H,10-11,14-15H2,1-5H3/t16-,17+
PubChem CID	11576203
ChEMBL	CHEMBL2364453
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	31.62 nM	DOI: http://dx.doi.org/10.6019/CHEMBL2364335	ChEMBL

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