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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	CHEMBL30075
Molecular formula	C15H15N3O3S
IUPAC name	6-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)naphthalene-2-sulfonamide
Molecular weight	317.363
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.3
Synonyms	6-Amino-naphthalene-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide BDBM50034436 L009162 SCHEMBL8784519
Inchi Key	AXCASGWUQSFEJM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H15N3O3S/c1-9-10(2)17-21-15(9)18-22(19,20)14-6-4-11-7-13(16)5-3-12(11)8-14/h3-8,18H,16H2,1-2H3
PubChem CID	10403526
ChEMBL	CHEMBL30075
IUPHAR	N/A
BindingDB	50034436
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	600.0 nM	PMID7861414	BindingDB,ChEMBL
IC50	660.0 nM	PMID7731020	ChEMBL
IC50	660.0 nM	PMID7731020	BindingDB

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