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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL266961
Molecular formula	C36H33N7O
IUPAC name	N-[(R)-[4-(4-ethylphenyl)-5-[2-(1H-indol-3-yl)ethyl]-1,2,4-triazol-3-yl]-(1H-indol-3-yl)methyl]-2-pyridin-2-ylacetamide
Molecular weight	579.708
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	5.8
Synonyms	BDBM50232278 (R)-N-((5-(2-(1H-indol-3-yl)ethyl)-4-(4-ethylphenyl)-4H-1,2,4-triazol-3-yl)(1H-indol-3-yl)methyl)-2-(pyridin-2-yl)acetamide
Inchi Key	AWYMMDJZZHLIMY-PGUFJCEWSA-N
Inchi ID	InChI=1S/C36H33N7O/c1-2-24-14-17-27(18-15-24)43-33(19-16-25-22-38-31-12-5-3-10-28(25)31)41-42-36(43)35(30-23-39-32-13-6-4-11-29(30)32)40-34(44)21-26-9-7-8-20-37-26/h3-15,17-18,20,22-23,35,38-39H,2,16,19,21H2,1H3,(H,40,44)/t35-/m1/s1
PubChem CID	44445609
ChEMBL	CHEMBL266961
IUPHAR	N/A
BindingDB	50232278
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.0 %	PMID18193826	ChEMBL
IC50	96.0 nM	PMID18193826	BindingDB,ChEMBL
Kb	34.0 nM	PMID18193826	ChEMBL

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