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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL1917359
Molecular formula	C24H35N3O2S
IUPAC name	N-[4-(3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl)butyl]-N-ethylquinoline-8-sulfonamide
Molecular weight	429.623
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.9
Synonyms	BDBM50357993
Inchi Key	AWWHYCGNIZANRQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H35N3O2S/c1-2-27(30(28,29)23-13-7-11-21-12-8-15-25-24(21)23)17-6-5-16-26-18-14-20-9-3-4-10-22(20)19-26/h7-8,11-13,15,20,22H,2-6,9-10,14,16-19H2,1H3
PubChem CID	54764323
ChEMBL	CHEMBL1917359
IUPHAR	N/A
BindingDB	50357993
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1950.0 nM	PMID22001327	BindingDB,ChEMBL

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