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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6117632
Molecular formula	C22H16F2N2O3
IUPAC name	6-[[2-(2,5-difluorophenyl)-5-methoxyindol-1-yl]methyl]pyridine-2-carboxylic acid
Molecular weight	394.378
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.3
Synonyms	BDBM119481 JZSRAEAMSHQMLU-UHFFFAOYSA-N 6-[2-(2,5-difluorophenyl)-5-methoxyindol-1-ylmethyl]pyridine-2-carboxylic acid CHEMBL3665575 US8680120, 25-41
Inchi Key	JZSRAEAMSHQMLU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H16F2N2O3/c1-29-16-6-8-20-13(9-16)10-21(17-11-14(23)5-7-18(17)24)26(20)12-15-3-2-4-19(25-15)22(27)28/h2-11H,12H2,1H3,(H,27,28)
PubChem CID	50908089
ChEMBL	CHEMBL3665575
IUPHAR	N/A
BindingDB	119481
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	25.0 nM	, None	BindingDB,ChEMBL

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