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GPCR

NameThromboxane A2 receptor
SpeciesRattus norvegicus (Rat)
GeneTbxa2r
Synonymprostanoid TP receptor
TP receptor
TXA2-R
TXR2
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProtP34978
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3156
IUPHAR346
DrugBankN/A

Ligand

NameCHEMBL160091
Molecular formulaC33H44N2O5
IUPAC name(Z)-6-[(1R,5S)-2-[[4-[2-(acetamidomethyl)phenyl]phenyl]methoxy]-5-(azepan-1-yl)cyclopentyl]oxyhex-4-enoic acid
Molecular weight548.724
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.1
SynonymsBDBM50391294
Inchi KeyJZIHLPQBKBILMV-NPBBFKMKSA-N
Inchi IDInChI=1S/C33H44N2O5/c1-25(36)34-23-28-11-6-7-12-29(28)27-16-14-26(15-17-27)24-40-31-19-18-30(35-20-8-2-3-9-21-35)33(31)39-22-10-4-5-13-32(37)38/h4,6-7,10-12,14-17,30-31,33H,2-3,5,8-9,13,18-24H2,1H3,(H,34,36)(H,37,38)/b10-4-/t30-,31?,33+/m0/s1
PubChem CID44374600
ChEMBLCHEMBL160091
IUPHARN/A
BindingDB50391294
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd125.89 nM, Bioorg. Med. Chem. Lett., (1991) 1:12:689BindingDB,ChEMBL

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