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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL349486
Molecular formula	C27H30ClN3O5S
IUPAC name	1-[2-(5-chloro-2-oxo-1,3-benzothiazol-3-yl)acetyl]-N-[(1-hydroxy-7-methoxy-3,4-dihydro-2H-naphthalen-1-yl)methyl]piperidine-4-carboxamide
Molecular weight	544.063
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.2
Synonyms	N-(1-Hydroxy-7-methoxytetralin-1-ylmethyl)-1-(2-oxo-5-chloro-2,3-dihydrobenzothiazole-3-ylacetyl)-4-piperidinecarboxamide 1-[2-(5-Chloro-2-oxo-benzothiazol-3-yl)-acetyl]-piperidine-4-carboxylic acid (1-hydroxy-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-amide BDBM50110567
Inchi Key	AWRSRAVGHHYUAZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H30ClN3O5S/c1-36-20-6-4-17-3-2-10-27(35,21(17)14-20)16-29-25(33)18-8-11-30(12-9-18)24(32)15-31-22-13-19(28)5-7-23(22)37-26(31)34/h4-7,13-14,18,35H,2-3,8-12,15-16H2,1H3,(H,29,33)
PubChem CID	44379101
ChEMBL	CHEMBL349486
IUPHAR	N/A
BindingDB	50110567
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.0 nM	PMID11859006	BindingDB,ChEMBL

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