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GPCR

Name	Alpha-2A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2A
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Adra-2 Adra-2a ADRA2 ADRA2R Adrenergic alpha 2A receptor adrenergic receptor Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoceptor Alpha-2A adrenoreceptor [ Show all ]
Disease	Attention deficit hyperactivity disorder Sexual dysfunction Pain
Length	450
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P08913
Protein Data Bank	N/A
GPCR-HGmod model	P08913
3D structure model	This predicted structure model is from GPCR-EXP P08913.
BioLiP	N/A
Therapeutic Target Database	T11448
ChEMBL	CHEMBL1867
IUPHAR	25
DrugBank	BE0000289

Ligand

Name	INDORAMIN
Molecular formula	C22H25N3O
IUPAC name	N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
Molecular weight	347.462
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	4.1
Synonyms	S052 ZINC1567 3-[2-(4-Benzamidopiperidino)ethyl]indole AKOS015994528 C22H25N3O DB08950 Indoramin (USAN/INN) Indoraminum MLS001182179 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide (Indoramin) SMR000567879 AC1L1PYQ Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)- GTPL501 Indoramina KS-00002WRM N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide Oprea1_130443 WY 21901 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole AF-0013 Benzamide, N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]- D04531 IDI1_016359 Indoramine [INN-French] Maybridge3_004972 N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide PDSP2_001083 SCHEMBL49517 Baratol CCG-41146 DTXSID7048370 Indoramin [USAN:BAN:INN] Indoraminum [INN-Latin] MolPort-002-914-870 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide(Indoramin) SR-01000631243-1 0Z802HMY7H AC1Q5FDP Benzamide, N-(1-(2-indol-3-ylethyl)-4-piperidyl)- CHEMBL279516 HMS1445B22 Indoramina [INN-Spanish] L001292 N-(1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl)benzamide # PDSP1_001099 PDSP2_001407 Wy-21901 3-[2-(4-Benzamido-1-piperidyl)ethyl]indole AJ-08048 BRN 0494035 INDORAMINN-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide MCULE-9172964530 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide SCHEMBL49518 BDBM50033113 CHEBI:135470 EINECS 248-041-5 Indoramin [USAN:INN:BAN] JXZZEXZZKAWDSP-UHFFFAOYSA-N N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide NCGC00165810-01 UNII-0Z802HMY7H 26844-12-2 ACM26844122 Benzamide, N-[1-(2-indol-3-ylethyl)-4-piperidyl]- D02LHR HMS2851P23 Indoramine LS-27034 N-[1-(2-Indol-3-ylethyl)-4-piperidyl]benzamide PDSP1_001423 [ Show all ]
Inchi Key	JXZZEXZZKAWDSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
PubChem CID	33625
ChEMBL	CHEMBL279516
IUPHAR	501
BindingDB	50033113
DrugBank	DB08950
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2240.0 nM	PMID7658428	BindingDB
Ki	2240.0 nM	PMID7658428	ChEMBL

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