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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL2086677
Molecular formula	C20H27N5O3
IUPAC name	tert-butyl 4-[5-[(3-methylpyridin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
Molecular weight	385.468
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	2.1
Synonyms	SCHEMBL1447897 BDBM50420848
Inchi Key	JXIQMANEVJFITM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H27N5O3/c1-15-11-21-6-5-16(15)14-27-17-12-22-18(23-13-17)24-7-9-25(10-8-24)19(26)28-20(2,3)4/h5-6,11-13H,7-10,14H2,1-4H3
PubChem CID	51030811
ChEMBL	CHEMBL2086677
IUPHAR	N/A
BindingDB	50420848
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	75.0 nM	PMID22545772	BindingDB,ChEMBL
Intrinsic activity	101.0 %	PMID22545772	ChEMBL

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