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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	SKF 38393
Molecular formula	C16H17NO2
IUPAC name	5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Molecular weight	255.317
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.5
Synonyms	SK&F-38393 SKF38393 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine AC1Q79Q0 BRN 1543419 cid_147514 MolPort-003-666-576 NCGC00024875-04 R(+)SKF38393 SK-383933 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride(SKF 38393) BDBM50004923 CCG-204528 GTPL935 NCGC00015299-04 SCHEMBL469578 SKF-38,393 1H-3-Benzazepine-7,8-diol,2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1) BRD-A88548664-001-02-3 Lopac0_000436 NCGC00024875-02 SK&F-383933 SKF38393(hydrochloride) 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (SK&F 38393) 5-21-05-00258 (Beilstein Handbook Reference) API0009306 BSPBio_002384 CTK5B5738 NCG-C00093856-01 PDSP1_001524 R-SK&F 38393 (+/-)-SKF-38393 159795-65-0 6-PHENYL-4-AZOBICYCLO[5.4.0]UNDECA-7,9,11-TRIENE-9,10-DIOL Biomol-NT_000034 CHEBI:110200 KS-00001CZ8 NCGC00015299-05 SK&F 38393 SKF-38393 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol AC1L1B1H BRD-A88548664-004-01-9 CHEMBL286080 LS-27997 NCGC00024875-03 PDSP2_001508 SK-38393 SPECTRUM1505101 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol(SKF 38393) 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol BCP16347 C16H17NO2 D0OU7P NCGC00015299-03 RS(+/-)SKF 383931-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol SKF 38393-A (A+/-)-SKF-38393 hydrochloride 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl- 67287-49-4 BPBio1_001229 CHEBI:131801 L000563 NCGC00015299-06 [ Show all ]
Inchi Key	JUDKOGFHZYMDMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2
PubChem CID	1242
ChEMBL	CHEMBL286080
IUPHAR	935
BindingDB	50004923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	100.0 nM	PMID1826762	PDSP,IUPHAR
Ki	124.0 nM	PMID21907583	BindingDB,ChEMBL

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