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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	UNII-YZC2Y51NHJ
Molecular formula	C16H17NO2
IUPAC name	(5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Molecular weight	255.317
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.5
Synonyms	SCHEMBL7941051 ZINC1996374 (1R)-2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol CHEBI:125624 CHEMBL24077 SKF 38393 (+) (R)-7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepinium 7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepinium(R(+)SKF38393) R(+)SKF 383931-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (1R)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol(SKF38393) BDBM50004822 SK&F-383933 (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol CHEBI:131800 CHEMBL503958 SKF-38393, (R)- (R)-SKF 38393 AC1OAA0J R-(+)-Skf 38393 YZC2Y51NHJ (1R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hyrobromide 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, (1R)- BDBM50274530 SK-383933 (R)-1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol 62751-59-1 CTK2B3174 UNII-R7TF327S2C component JUDKOGFHZYMDMF-CQSZACIVSA-N (+)-SKF-38393 (R)-SKF-38393 AJ-32307 [ Show all ]
Inchi Key	JUDKOGFHZYMDMF-CQSZACIVSA-N
Inchi ID	InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
PubChem CID	6852376
ChEMBL	CHEMBL24077
IUPHAR	N/A
BindingDB	50004822, 50274530
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID1652023	BindingDB,ChEMBL
IC50	<10000.0 nM	PMID1533424	BindingDB,ChEMBL
IC50	3750.0 nM	PMID1971308	BindingDB,ChEMBL
K0.5	1870.0 nM	PMID7608904	ChEMBL
Ki	1621.0 nM	PMID1356154	BindingDB
Ki	2900.0 nM	PMID9171869	BindingDB,ChEMBL
Ki	6865.0 nM	PMID1833546	BindingDB,ChEMBL
Ki	6870.0 nM	PMID1652023	BindingDB,ChEMBL
Ki	9300.0 nM	PMID2415793, PMID1397049	BindingDB
Ki	9560.0 nM	PMID1975644, PMID1840645	BindingDB

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