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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL2068743
Molecular formula	C27H30N4O3
IUPAC name	[1-(naphthalen-1-ylmethyl)piperidin-2-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone
Molecular weight	458.562
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.8
Synonyms	SR-02000001252 SR-02000001252-1
Inchi Key	AWDXTIULFGSRCC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H30N4O3/c32-27(29-18-16-28(17-19-29)23-11-13-24(14-12-23)31(33)34)26-10-3-4-15-30(26)20-22-8-5-7-21-6-1-2-9-25(21)22/h1-2,5-9,11-14,26H,3-4,10,15-20H2
PubChem CID	53234156
ChEMBL	CHEMBL2068743
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<20000.0 nM	PubChem BioAssay data set	ChEMBL

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