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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL2036315
Molecular formulaC26H32N2O5S
IUPAC name4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(pyridin-3-ylmethoxy)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
Molecular weight484.611
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP2.3
SynonymsBDBM50385125
SCHEMBL10210629
Inchi KeyJSGJBDBGONKGOZ-UCQVOXAISA-N
Inchi IDInChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
PubChem CID57894065
ChEMBLCHEMBL2036315
IUPHARN/A
BindingDB50385125
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5019.0 nMPMID22546206BindingDB,ChEMBL

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