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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Mus musculus (Mouse)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	Q9ERZ4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3197
IUPHAR	14
DrugBank	N/A

Ligand

Name	CHEMBL76063
Molecular formula	C11H16N2O5
IUPAC name	methyl 2-(8-methyl-2,4-dioxo-1-oxa-3,8-diazaspiro[4.5]decan-3-yl)acetate
Molecular weight	256.258
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	0.0
Synonyms	8-Methyl-2,4-dioxo-1-oxa-3,8-diazaspiro[4.5]decane-3-acetic acid methyl ester (8-Methyl-2,4-dioxo-1-oxa-3,8-diaza-spiro[4.5]dec-3-yl)-acetic acid methyl ester BDBM50044700
Inchi Key	JPSFNAICVHINOA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H16N2O5/c1-12-5-3-11(4-6-12)9(15)13(10(16)18-11)7-8(14)17-2/h3-7H2,1-2H3
PubChem CID	14956869
ChEMBL	CHEMBL76063
IUPHAR	N/A
BindingDB	50044700
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
MED	<30.0 mg kg-1	PMID8360873	ChEMBL

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