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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL1836104
Molecular formula	C23H28N2O2
IUPAC name	N-[(1R,5R)-8-(oxolan-2-ylmethyl)-8-azabicyclo[3.2.1]octan-3-yl]naphthalene-1-carboxamide
Molecular weight	364.489
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BDBM50354099
Inchi Key	AVTQCLISYQTDGJ-LEAGNCFPSA-N
Inchi ID	InChI=1S/C23H28N2O2/c26-23(22-9-3-6-16-5-1-2-8-21(16)22)24-17-13-18-10-11-19(14-17)25(18)15-20-7-4-12-27-20/h1-3,5-6,8-9,17-20H,4,7,10-15H2,(H,24,26)/t18-,19-,20?/m1/s1
PubChem CID	56671946
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50354099
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4000.0 nM	PMID21816515	BindingDB

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