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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL568165
Molecular formula	C36H40N4O6S2
IUPAC name	N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide
Molecular weight	688.858
Hydrogen bond acceptor	10
Hydrogen bond donor	1
XlogP	5.6
Synonyms	SCHEMBL1472010 BDBM50302243 N-((R)-4-(3,4-dimethoxyphenyl)-4-(1,3-dioxo-4-(4-((R)-1-phenylethyl)piperazin-1-yl)isoindolin-2-yl)butyl)thiophene-2-sulfonamide
Inchi Key	JOTYMLKDQAFRFK-VAVYLYDRSA-N
Inchi ID	InChI=1S/C36H40N4O6S2/c1-25(26-10-5-4-6-11-26)38-19-21-39(22-20-38)30-13-7-12-28-34(30)36(42)40(35(28)41)29(27-16-17-31(45-2)32(24-27)46-3)14-8-18-37-48(43,44)33-15-9-23-47-33/h4-7,9-13,15-17,23-25,29,37H,8,14,18-22H2,1-3H3/t25-,29-/m1/s1
PubChem CID	23627722
ChEMBL	CHEMBL568165
IUPHAR	N/A
BindingDB	50302243
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	240.0 nM	PMID19731961	BindingDB,ChEMBL
Ki	49.0 nM	PMID19731961	BindingDB,ChEMBL

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