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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL608384
Molecular formulaC14H15ClN2O2
IUPAC name(2S)-2-(4-chlorophenyl)-3-methyl-N-(1,2-oxazol-3-yl)butanamide
Molecular weight278.736
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.5
SynonymsBDBM50305962
rac-(S)-2-(4-chlorophenyl)-N-(isoxazol-3-yl)-3-methylbutanamide
Inchi KeyJKXABPZOYWUDOA-ZDUSSCGKSA-N
Inchi IDInChI=1S/C14H15ClN2O2/c1-9(2)13(10-3-5-11(15)6-4-10)14(18)16-12-7-8-19-17-12/h3-9,13H,1-2H3,(H,16,17,18)/t13-/m0/s1
PubChem CID46226179
ChEMBLCHEMBL608384
IUPHARN/A
BindingDB50305962
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy90.0 %PMID20005104ChEMBL
IC5036000.0 nMPMID20005104BindingDB,ChEMBL

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