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Name | 5-hydroxytryptamine receptor 1B |
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Species | Rattus norvegicus (Rat) |
Gene | Htr1b |
Synonym | HTR1D2 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 5-HT1Dbeta 5-HT1DB 5-HT1B serotonin receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 386 |
Amino acid sequence | MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG |
UniProt | P28564 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3459 |
IUPHAR | 2 |
DrugBank | N/A |
Name | CHEMBL51985 |
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Molecular formula | C27H41N2O4+ |
IUPAC name | 4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl-(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-methyl-propylazanium |
Molecular weight | 457.635 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 4.6 |
Synonyms | CHEMBL1178971 BDBM50036872 [4-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-butyl]-(5-methoxy-chroman-3-yl)-methyl-propyl-ammonium; iodide |
Inchi Key | JKDNPVDWERGGAV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H41N2O4/c1-4-15-29(2,21-17-22-23(32-3)10-9-11-24(22)33-20-21)16-8-7-14-28-25(30)18-27(19-26(28)31)12-5-6-13-27/h9-11,21H,4-8,12-20H2,1-3H3/q+1 |
PubChem CID | 10008463 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50036872 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <1000000.0 nM | PMID7912735 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417