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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CYPROHEPTADINE
Molecular formula	C21H21N
IUPAC name	1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine
Molecular weight	287.406
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	4.7
Synonyms	Eiproheptadine 129-03-3 KB-238615 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine NCGC00015252-01 41354-29-4 NCGC00015252-09 Axoprol PDSP1_001229 BRD-K28143534-001-03-0 Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl- CAS-969-33-5 SCHEMBL4021 Ciprovit ZINC968264 Cyproheptadinum Dihexazin GTPL277 16621-EP2295409A1 Lopac0_000246 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine NCGC00015252-04 NCGC00015252-13 BIDD:GT0324 Periactin (TN) BRN 1685976 Prestwick1_000103 CHEBI:4046 Tocris-0996 Cyproheptadiene D00TLN DSSTox_CID_2872 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine 1-methyl-4-{tricyclo[9.4.0.0;{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylidene}piperidine HSDB 3048 MK 141 4-(dibenzo[[?],[?]][7]annulen-11-ylidene)-1-methyl-piperidine NCGC00015252-07 AKOS004119847 NCGC00024293-05 BPBio1_000155 Peritol C06935 Reactin Ciproheptadina UNII-2YHB6175DO Cyproheptadine (INN) DB00434 DTXSID8022872 FT-0631755 129C033 L001016 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene NCGC00015252-02 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene NCGC00015252-10 BBL010977 PDSP2_001213 BRD-K28143534-003-03-6 Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl- CCG-204341 SPBio_002025 Ciprovit (TN) Cyproheptadinum [INN-Latin] DL-136 H2428 16621-EP2314590A1 LS-114933 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine NCGC00015252-05 AC1L1ER8 NCGC00024293-02 Biomol-NT_000131 Periactine BSPBio_000086 Prestwick2_000103 Tox21_110112 Cyproheptadin D07765 DSSTox_GSID_22872 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine 1-methyl-4-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}piperidine JJCFRYNCJDLXIK-UHFFFAOYSA-N 2YHB6175DO MolPort-002-507-777 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine NCGC00015252-08 AN-43631 Oprea1_498140 BRD-K28143534-001-01-4 Peritol (Salt/Mix) CAS-129-03-3 SBI-0050234.P002 Ciproheptadina [INN-Spanish] Viternum Cyproheptadine [INN:BAN] Dibenzosuberonone/Cyproheptadine EINECS 204-928-9 Glutodina 16621-EP2281563A1 Lopac-C-6022 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine NCGC00015252-03 5-20-08-00500 (Beilstein Handbook Reference) NCGC00015252-12 BDBM50017721 Periactin BRD-K28143534-003-14-3 Prestwick0_000103 CCRIS 5232 STK802098 Cypoheptadine cyproheptidine Dronactin 1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine HMS2090P20 16621-EP2316459A1 MCULE-3352282545 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine NCGC00015252-06 AJ-24591 NCGC00024293-04 BPBio1_000096 Periactinol C-36401 Prestwick3_000103 CHEMBL516 Tox21_110112_1 DSSTox_RID_76768 [ Show all ]
Inchi Key	JJCFRYNCJDLXIK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
PubChem CID	2913
ChEMBL	CHEMBL516
IUPHAR	277
BindingDB	50017721
DrugBank	DB00434
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	281.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	130.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	134.0 nM	PMID8226867	PDSP,BindingDB
Ki	150.0 nM	PMID8522988	PDSP,BindingDB
Ki	158.489 nM	PMID8522988	IUPHAR

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