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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	tolazoline
Molecular formula	C10H12N2
IUPAC name	2-benzyl-4,5-dihydro-1H-imidazole
Molecular weight	160.22
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.6
Synonyms	LS-79571 NSC 35110 ACMC-209mh8 Prestwick1_000060 B3806 SC-96012 Benzolin (VAN) Spectrum_000731 BSPBio_000219 Tolazolina Ciba 3259 UNII-CHH9H12AQ3 Divascol IDI1_000328 2-(phenylmethyl)-4,5-dihydro-1H-imidazole KBio2_001211 2-Benzyl-4,5-imidazoline MolPort-002-626-489 Olitensol AN-23625 Pridazole Benzalolin SPBio_002140 Benzylimidazoline STL362893 CAS-59-97-2 Tolazoline (INN) D03RZV Vasodilatan EINECS 200-448-9 059T983 Imidaline 2-Benzyl-2-imidazoline KBio3_001568 2-Benzylimidazoline, 99% 4CH-003537 NCGC00016271-03 AB0010715 Prefaxil Artonil SBB003964 Benzidazol Spectrum4_000357 BRD-K46211610-003-15-0 Tolazine [veterinary] (TN) CHEMBL770 Tolazolinum DB00797 GTPL7310 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(9CI) KB-61755 2-Benzyl-4,5-dihydro-1H-imidazole # L000960 MCULE-5694308124 59-97-2 (mono-hydrochloride) NSC-35110 AJ-11901 Prestwick2_000060 BBL027502 SCHEMBL34961 Benzolin (vasodilator) ST24040015 BSPBio_002068 Tolazolina [INN-Spanish] cid_6048 Vasimid DivK1c_000328 IMI037 2-(phenylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride KBio2_003779 2-BENZYL-4,5-IMIDAZOLINE HCl 2-IMIDAZOLINE, 2-BENZYL- NCGC00016271-01 AB00053555-12 Peripherine AN-41799 Priscol Benzazolin Spectrum2_001204 BPBio1_000241 TC-122147 CHEBI:28502 Tolazoline Monohydrochloride D08614 WLN: T5M CN BUTJ B1R FD7203 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- JIVZKJJQOZQXQB-UHFFFAOYSA-N 2-benzyl-2-imidazoline;hydrochloride KBioGR_000793 5-23-06-00488 (Beilstein Handbook Reference) NINDS_000328 AC1L1KHM Prestwick0_000060 AS-49302 SBI-0051536.P003 Benzolin Spectrum5_001788 BRN 0128757 Tolazolin CHH9H12AQ3 Tolazolinum [INN-Latin] Dilatol ASI HY-A0066 1H-Imidazole,5-dihydro-2-(phenylmethyl)- KBio1_000328 2-benzyl-4,5-dihydro-1H-imidazole;hydrochloride Lambril MFCD00005182 59-98-3 NSC35110 AKOS000357643 Prestwick3_000060 BDBM55436 SPBio_000988 Benzolin (vasodilator) (VAN) ST45026160 C07147 CS-3181 Vasodil DTXSID3023683 Imidalin 2-benzyl imidazoline KBio2_006347 2-Benzylimidazoline 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole NCGC00016271-02 AB00053555_14 Phenylmethylimidazoline ANW-33402 Priscoline Benzazoline Spectrum3_000594 BRD-K46211610-003-05-1 Tolazine [veterinary] Tolazoline [INN:BAN] ZINC125006 FT-0603251 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- (9CI) Kasimid 2-Benzyl-4,5-dihydro-1H-imidazole KBioSS_001211 [ Show all ]
Inchi Key	JIVZKJJQOZQXQB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
PubChem CID	5504
ChEMBL	CHEMBL770
IUPHAR	7310
BindingDB	55436
DrugBank	DB00797
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	3715.0 nM	PMID9605427	IUPHAR
Ki	3715.35 nM	PMID9605427	BindingDB

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