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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Rattus norvegicus (Rat)
Gene	Htr1b
Synonym	HTR1D2 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 5-HT1Dbeta 5-HT1DB 5-HT1B serotonin receptor 5-HT1B receptor 5-HT1B 5-HT-1B Serotonin receptor 1B [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProt	P28564
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3459
IUPHAR	2
DrugBank	N/A

Ligand

Name	disulfiram
Molecular formula	C10H20N2S4
IUPAC name	diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Molecular weight	296.524
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	1,N-diethylthioformamide] MLS000758264 BSPBio_001930 Spectrum3_000405 AB00051976-20 N,N-diethylcarbamodithioic acid [[diethylamino(sulfanylidene)methyl]thio] ester CHEMBL964 ENT 27,340 Abstensyl (Argentina) NCGC00016000-06 CTK3J1569 Ethyl Thiudad AI3-27340 NCGC00016000-14 Disulfarim ethyltuex Antabus NCGC00094423-07 Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material FT-0631502 Antaethyl Noxal Disulfirm HMS2095C16 Anti-ethyl Opera_ID_224 DTXSID1021322 Hocakrotenalnci-C02959 Antivitium (Spain) Prestwick_182 KBio2_004058 BDBM50058655 RTR-030253 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetra KSC491K6T Bis(N,N-diethylthiocarbamoyl)disulphide SC-75356 STL069539 Tenurid Tetraethyldithiuram disulfide Tetraethylthiuram disulphide Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl- Thiuram E TR-030253 UPCMLD-DP090:001 Bonibal Soxinol TET 155-01-1 MolPort-001-792-519 CAS-97-77-8 AB00051976_22 NCGC00016000-01 Contralin Esperal AC1L1F7H NCGC00016000-09 DB00822 Ethyl Tuads Rodform Alcophobin NCGC00094423-01 Disulfiram (Antabuse) Exhoran Antabuse (TN) NCI-C02959 Disulfirame [DCIT] HMS1568C16 Antetan NSC 25953 Disulphuram HMS3371B21 Antietanol Pharmakon1600-01500262 EC 202-607-8 HY-B0240 AUZONCFQVSMFAP-UHFFFAOYSA-N Refusal KBioGR_000895 Bis(diethylthiocarbamoyl) disulfide SAM001247028 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane LP01164 Spectrum_001010 Stopety TETD Tetraethylthiram disulphide Tetraethylthiurium disulfide Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl- Tox21_110280 TTS WLN: 2N2 & YUS & S 2 MFCD00009048 BRD-K32744045-001-17-1 SPECTRUM1500262 A845750 N,N,N',N'-Tetraethylthiuram disulfide CHEBI:4659 Abstenisil NCGC00016000-04 Cronetal Etabus Accel TET-R NCGC00016000-12 Disetil Ethyldithiurame Ancazide ET NCGC00094423-05 Disulfiram, British Pharmacopoeia (BP) Reference Standard Formamide, 1,1'-dithiobis(N,N-diethylthio- Antaenyl Nocceler TET Disulfiramum HMS2090C18 Anteyl NSC25953 DSSTox_GSID_21322 HMS3712C16 Antikol Prestwick2_000097 Ekagom TEDS KB-81054 B0479 Ro-Sulfram-500 (USA) 1,1'',1'''',1''''''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane KS-000011OS Bis(diethylthiocarbamyoyl)disulfide SBB058706 1,1'-Dithiobis[N,N-diethylthioformamide] ZINC1529266 SR-01000076145-5 T 1132 Tetradine Tetraethylthiuram disulfide, 97% Teturamin Thireranide Tox21_400072 UNII-TR3MLJ1UAI SCHEMBL27213 1-(diethylthiocarbamoyldisulfanyl)-N,N-diethyl-methanethioamide MLS001076475 C01692 Spectrum4_000228 AB00051976-21 N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide CJ-05170 Ephorran Abstinil NCGC00016000-07 D00131 Ethyl Thiurad AKOS000120201 NCGC00016000-15 Disulfide, bis(diethylthiocarbamoyl) Etyl Tuex Antabus (TN) NCGC00254447-01 Disulfiram, United States Pharmacopeia (USP) Reference Standard Gababentin Antaetil Noxal (VAN) Disulfram HMS2230K06 Antiaethan Perkacit TETD Dupon 4472 HS-0057 ANW-40884 Q-201812 KBio2_006626 Bis((diethylamino)thioxomethyl) disulfide S00294 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane Lopac-T-1132 bis-(diethyl-thiocarbamyl)-disulfide Stopaethyl Tenutex Tetraethylthioperoxydicarbonic diamide Tetraethylthiuram sulfide Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl- Thiuranide TR3MLJ1UAI Usaf B-33 BPBio1_000060 SPBio_001191 N,N',N'-Tetraethylthiuram disulfide CCG-39549 AB00051976_25 NCGC00016000-02 Contrapot Esperal [France] AC1Q2YXI NCGC00016000-10 Dicupral Ethyl Tuex Alk-aubs NCGC00094423-02 Disulfiram (JP17/USP/INN) Exhorran Antabuse;Antabus Nocbin Disulfiramo HMS1920I16 Antethyl NSC-25953 DL-379 HMS3393M17 Antiethanol Prestwick0_000097 EINECS 202-607-8 I14-53917 Aversan Refusal [Netherlands] KBioSS_001490 Bis(diethylthiocarbamoyl)disulphide Sanceler TET 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)nitrilo]}tetraethane LS-2031 SR-01000076145 Stopetyl Tetidis Tetraethylthiuram Tetraetil Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl- Tox21_110280_1 TTS x Z-0809 MLS000069818 BSPBio_000054 Spectrum2_001176 AB00051976 N,N,N',N'-Tetraethylthiuram disulphide Ekaland TETD Abstensil NCGC00016000-05 CS-2209 Ethyl Thiram ACMC-209s92 NCGC00016000-13 Disulfan ethylthiudad Antab use NCGC00094423-06 Disulfiram, European Pharmacopoeia (EP) Reference Standard Formamide,1'-dithiobis(N,N-diethylthio)- Antaethan Nocceler TET-G Disulfiramum [INN-Latin] HMS2091O22 Anthethyl NSC756748 DSSTox_RID_76082 Hoca Antivitium Prestwick3_000097 Ekagom TETDS KBio2_001490 BCP07331 Robac TET 1,1''-dithiobis(N,N-diethylthioformamide) KS-000046JU Bis(N,N-diethylthiocarbamoyl) disulfide SBI-0051131.P004 1,1;-Dithiobis(N,N-diethylthioformamide SR-01000076145-8 TATD tetraethyl thiuram disulfide Tetraethylthiuram disulfide, >=97.0% (S) THIOCID Thiuram disulfide, tetraethyl- Tox21_501164 UPCMLD-DP090 SMR000059171 11078-22-1 MLS001423963 C10H20N2S4 AB00051976-23 NC00063 CJ-23871 Espenal Abstinyl NCGC00016000-08 D0X5SD Ethyl tuads Akrochem TETD NCGC00016000-18 EU-0101164 Antabuse NCGC00261849-01 Disulfirame GTPL7168 Antalcol NSC 190940 Disulfuram HMS3263J09 Anticol Perkait TETD Dupont fungicide 4472 HSDB 3317 ARONIS24121 R531 KBio3_001150 Bis((diethylamino)thioxomethyl)disulphide s1680 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetraethane Lopac0_001164 Bis[(diethylamino)thioxomethyl] disulfide Spectrum5_001590 Stopethyl tet raethylthiuram Tetraethylthiram disulfide Tetraethylthiuran disulfide Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl- Tillram TTD W0030 MCULE-1443050857 BRD-K32744045-001-05-6 SPBio_001993 97-77-8 N,N,N'',N''-tetraethylthiuram disulfide CCRIS 582 AB2000216 NCGC00016000-03 CPD000059171 Eta bus Accel TET NCGC00016000-11 diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate Ethyldithiourame AN-24463 NCGC00094423-03 Disulfiram [USP:INN:BAN:JAN] Formamide, 1,1'-dithiobis(N,N-diethylthio)- Antadix Nocceler Disulfiramo [INN-Spanish] HMS2051M17 Antetil NSC-756748 DSSTox_CID_1322 HMS3655I19 Antietil Prestwick1_000097 Ekagom DTET InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H Averzan Ro-sulfiram (diethylamino){[(diethylamino)thioxomethyl]disulfanyl}methane-1-thione Krotenal Bis(diethylthiocarbamyl) disulfide Sanceler TET-G 1,1'-Dithiobis(N,N-diethylthioformamide) Z1522553469 SR-01000076145-1 SW196492-4 Tetradin Tetraethylthiuram disulfide Teturam Thioperoxydicarbonic diamide, tetraethyl- Tox21_300403 Tuads, ethyl [ Show all ]
Inchi Key	AUZONCFQVSMFAP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
PubChem CID	3117
ChEMBL	CHEMBL964
IUPHAR	N/A
BindingDB	50058655
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4720.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	2145.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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