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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	CHEMBL2153447
Molecular formula	C26H25N3O2
IUPAC name	N-[[4-(3-methoxyphenyl)phenyl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide
Molecular weight	411.505
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM50393124
Inchi Key	JGVSDYAGZPHABS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H25N3O2/c1-31-24-8-2-5-22(17-24)20-12-10-19(11-13-20)18-28-25(30)9-3-7-23-15-14-21-6-4-16-27-26(21)29-23/h2,4-6,8,10-17H,3,7,9,18H2,1H3,(H,28,30)
PubChem CID	71449506
ChEMBL	CHEMBL2153447
IUPHAR	N/A
BindingDB	50393124
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1000.0 nM	PMID21571530	BindingDB,ChEMBL

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