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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL596151
Molecular formulaC13H15ClN2O2S2
IUPAC name1-(4-chlorophenyl)-2-methyl-N-(1,3-thiazol-2-yl)propane-1-sulfonamide
Molecular weight330.845
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.7
SynonymsBDBM50305940
rac-1-(4-chlorophenyl)-2-methyl-N-(thiazol-2-yl)propane-1-sulfonamide
Inchi KeyJFTNWLAPKFTWOJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H15ClN2O2S2/c1-9(2)12(10-3-5-11(14)6-4-10)20(17,18)16-13-15-7-8-19-13/h3-9,12H,1-2H3,(H,15,16)
PubChem CID46226104
ChEMBLCHEMBL596151
IUPHARN/A
BindingDB50305940
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>30.0 %PMID20005104ChEMBL
IC50<100000.0 nMPMID20005104BindingDB,ChEMBL

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