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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL211311
Molecular formula	C35H31ClFN5O2
IUPAC name	benzyl 4-[[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-[4-(3-cyanophenyl)phenyl]methyl]piperidine-1-carboxylate
Molecular weight	608.114
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	6.6
Synonyms	BDBM50186775 4-[[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-(3''-cyano-biphenyl-4-yl)-methyl]-piperidine-1-carboxylic acid benzyl ester
Inchi Key	JFMIBDAAZFALFW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H31ClFN5O2/c36-29-18-31-32(19-30(29)37)41-33(40-31)21-39-34(26-11-9-25(10-12-26)28-8-4-7-24(17-28)20-38)27-13-15-42(16-14-27)35(43)44-22-23-5-2-1-3-6-23/h1-12,17-19,27,34,39H,13-16,21-22H2,(H,40,41)
PubChem CID	44412686
ChEMBL	CHEMBL211311
IUPHAR	N/A
BindingDB	50186775
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	48.0 nM	PMID16690312	BindingDB,ChEMBL

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