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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL434591
Molecular formula	C25H25N3O3S
IUPAC name	3-[2-(9-methoxy-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl)ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
Molecular weight	447.553
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.2
Synonyms	(Cis)3-[2-(9-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-1H-benzo[4,5]thieno[3,2-d]pyrimidine-2,4-dione BDBM50087462
Inchi Key	AUTDQXWEIXAWCN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H25N3O3S/c1-31-19-7-4-5-15-9-10-16-13-27(14-18(16)21(15)19)11-12-28-24(29)23-22(26-25(28)30)17-6-2-3-8-20(17)32-23/h2-8,16,18H,9-14H2,1H3,(H,26,30)
PubChem CID	44288468
ChEMBL	CHEMBL434591
IUPHAR	N/A
BindingDB	50087462
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8.67 nM	PMID10780916	BindingDB,ChEMBL

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