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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS003231005
Molecular formula	C19H14BrClN2O
IUPAC name	6-bromo-3-[(3-chlorophenyl)methyl]-2-(furan-2-yl)-8-methylimidazo[1,2-a]pyridine
Molecular weight	401.688
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	6.2
Synonyms	BDBM97190 cid_53299527 6-bromanyl-3-[(3-chlorophenyl)methyl]-2-(furan-2-yl)-8-methyl-imidazo[1,2-a]pyridine 6-bromo-3-[(3-chlorophenyl)methyl]-2-(furan-2-yl)-8-methylimidazo[1,2-a]pyridine 6-bromo-3-(3-chlorobenzyl)-2-(2-furyl)-8-methyl-imidazo[1,2-a]pyridine CHEMBL2136078 SMR001913570 6-bromo-3-[(3-chlorophenyl)methyl]-2-(2-furanyl)-8-methylimidazo[1,2-a]pyridine [ Show all ]
Inchi Key	JESMIUAIFXBPCA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14BrClN2O/c1-12-8-14(20)11-23-16(10-13-4-2-5-15(21)9-13)18(22-19(12)23)17-6-3-7-24-17/h2-9,11H,10H2,1H3
PubChem CID	53299527
ChEMBL	CHEMBL2136078
IUPHAR	N/A
BindingDB	97190
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	22387.2 nM	PubChem BioAssay data set	ChEMBL

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