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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	NAXAGOLIDE
Molecular formula	C15H21NO2
IUPAC name	(4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol
Molecular weight	247.338
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.4
Synonyms	BCP9000980 DTXSID60236782 Naxagolida [INN-Spanish] RL05487 1,2,3,4a,5,6-hexahydro-9-hydroxy-4-n-propyl-4H-naphth(1,2-b)(1,4)oxazine AC1L1N70 CHEMBL1288585 l-64739 Naxagolidum ZINC22064446 (+)-PHNO 3,4,4A,5,6,10B-hexahydro-4-propyl-2H-naphth(1,2-B)(1,4)oxozin-9-ol 4-propyl-9-hydroxynaphoxazine API0007626 D0TH1Z N-0500 PHNO (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol BDBM50020217 J-501357 SCHEMBL221758 (+)-4-propyl-9-hydroxynaphoxazine 22Z7E0X6OF AKOS005146337 LS-178034 Naxagolidum [INN-Latin] [11C]-(+)-(4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol (4ar)-3,4,4a\|A,5,6,10b\|A-hexahydro-4-propyl-2h-naphth[1,2-b]-1,4-oxazin-9-ol 4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol 4-propyl-9-hydroxynaphthoxazine BCP02364 dopazinol Naxagolida PHNO,(+) (4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol 88058-88-2 BDBM50331552 JCSREICEMHWFAY-HUUCEWRRSA-N Naxagolide [INN] UNII-22Z7E0X6OF (+)-4-Propyl-9-hydroxynaphthoxazine 2H-Naphth(1,2-b)-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR-trans)- 4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine AN-16576 CHEMBL69271 N 0500 Nazagolide (4ar,10br)-3,4,4a,5,6,10b-hexahydro-4-propyl-2h-naphth(1,2-b)-1,4-oxazin-9-ol [ Show all ]
Inchi Key	JCSREICEMHWFAY-HUUCEWRRSA-N
Inchi ID	InChI=1S/C15H21NO2/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16/h3,5,10,14-15,17H,2,4,6-9H2,1H3/t14-,15-/m1/s1
PubChem CID	57533
ChEMBL	CHEMBL69271
IUPHAR	N/A
BindingDB	50020217, 50331552
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Change	-14.0 %	PMID15943487	ChEMBL

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