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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	Eicosapentaenoic acid
Molecular formula	C20H30O2
IUPAC name	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Molecular weight	302.458
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.6
Synonyms	HMS1989C10 (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Icosapentaenoic acid 5,8,11,14,17-Eicosapentaenoate MFCD00065716 SR-01000946647 all-cis-icosa-5,8,11,14,17-pentaenoic acid UNII-F85N2YHE4E component JAZBEHYOTPTENJ-JLNKQSITSA-N C20:5 omega-3 cis-5,8,11,14,17-EPA DSSTox_RID_79612 EPA;Timnodonic acid HY-B0660 (all-Z)-delta5,8,11,14,17-Eicosapentaenoic acid IDI1_033798 5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)- (9CI) NCGC00161344-01 AAN7QOV9EA Timnodonic acid AS-53730 CC-25864 cis-5,8,11,14,17-Eicosapentaenoic acid D08061 eicosapentaenoate FA 20:5 (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid Icosapent [INN] 25377-48-4 L001256 5,8,11,14,17-Icosapentaenoate NCGC00161344-04 all-cis-5,8,11,14,17-eicosapentaenoic acid UNII-9B22238JYI component JAZBEHYOTPTENJ-JLNKQSITSA-N BSPBio_001328 CCRIS 3279 cis-5,8,11,14,17-Eicosapentaenoic acid, >=99% DSSTox_CID_21023 EPA HMS1361C10 HMS3402C10 (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid Icosapento 5,8,11,14,17-EICOSAPENTAENOIC ACID Miraxion 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoate SR-01000946647-1 all-cis-icosapentaenoate z,z,z,z,z-eicosa-5,8,11,14,17-pentaenoic acid C20:5n-3,6,9,12,15 CHEMBL460026 cis-Delta(5,8,11,14,17)-eicosapentaenoic acid DTXSID9041023 Eye Q (5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoic acid Icosapent 10417-94-4 J-001125 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)- NCGC00161344-02 AC1L9JFR Tox21_111991 BDBM50242349 CCG-207957 cis-5,8,11,14,17-Eicosapentaenoic acid, 500 mug/mL in ethanol, certified reference material GK4054 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid Icosapentaenoate 3gwx LMFA01030759 5,8,11,14,17-Icosapentaenoic acid SCHEMBL20469 all-cis-5,8,11,14,17-icosapentaenoic acid UNII-AAN7QOV9EA C06428 CHEBI:28364 cis-5,8,11,14,17-Eicosapentaenoic acid, analytical standard DSSTox_GSID_41023 EPA [drug] HMS1791C10 HMS3649D19 (all-Z)-5,8,11,14,17-Eicosapentaenoic acid Icosapentum 5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)- MolPort-003-933-180 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid Timnodonate all-cis-icosapentaenoic acid ZINC4474603 CAS-10417-94-4 cis-5,8,11,14,17-eicosapentaenoate CS-2895 Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) Eye-Q (5Z,8Z,11 Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate Icosapent (INN) 1755AH JAZBEHYOTPTENJ-JLNKQSITSA-N 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)- (8CI) NCGC00161344-03 AKOS027470327 UNII-71M78END5S component JAZBEHYOTPTENJ-JLNKQSITSA-N BRD-K47192521-001-02-1 CCG-208136 cis-5,8,11,14,17-Eicosapentaenoic acid, >=85%, liquid DB00159 Eicosapentaenoic acid, 5,8,11,14,17-(Z,Z,Z,Z,Z)- GTPL3362 [ Show all ]
Inchi Key	JAZBEHYOTPTENJ-JLNKQSITSA-N
Inchi ID	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
PubChem CID	446284
ChEMBL	CHEMBL460026
IUPHAR	N/A
BindingDB	50242349
DrugBank	DB00159
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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