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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Oxoeicosanoid receptor 1
Species	Homo sapiens (Human)
Gene	OXER1
Synonym	R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 G-protein coupled receptor TG1019 G-protein coupled receptor R527 G-protein coupled receptor 170 5-oxo-ETE receptor 5-oxo-ETE G-protein coupled receptor TG1019 [ Show all ]
Disease	N/A
Length	423
Amino acid sequence	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProt	Q8TDS5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628461
IUPHAR	271
DrugBank	N/A

Ligand

Name	Eicosapentaenoic acid
Molecular formula	C20H30O2
IUPAC name	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Molecular weight	302.458
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.6
Synonyms	BDBM50242349 CCG-207957 cis-5,8,11,14,17-Eicosapentaenoic acid, 500 mug/mL in ethanol, certified reference material GK4054 (5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoic acid Icosapent 10417-94-4 J-001125 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)- NCGC00161344-02 AC1L9JFR Tox21_111991 UNII-AAN7QOV9EA C06428 CHEBI:28364 cis-5,8,11,14,17-Eicosapentaenoic acid, analytical standard DSSTox_GSID_41023 EPA [drug] HMS1791C10 (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid Icosapentaenoate 3gwx LMFA01030759 5,8,11,14,17-Icosapentaenoic acid SCHEMBL20469 all-cis-5,8,11,14,17-icosapentaenoic acid all-cis-icosapentaenoic acid ZINC4474603 CAS-10417-94-4 cis-5,8,11,14,17-eicosapentaenoate CS-2895 Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) Eye-Q (5Z,8Z,11 Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid HMS3649D19 (all-Z)-5,8,11,14,17-Eicosapentaenoic acid Icosapentum 5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)- MolPort-003-933-180 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid Timnodonate UNII-71M78END5S component JAZBEHYOTPTENJ-JLNKQSITSA-N BRD-K47192521-001-02-1 CCG-208136 cis-5,8,11,14,17-Eicosapentaenoic acid, >=85%, liquid DB00159 Eicosapentaenoic acid, 5,8,11,14,17-(Z,Z,Z,Z,Z)- GTPL3362 (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate Icosapent (INN) 1755AH JAZBEHYOTPTENJ-JLNKQSITSA-N 5,8,11,14,17-Eicosapentaenoic acid, (all-Z)- (8CI) NCGC00161344-03 AKOS027470327 UNII-F85N2YHE4E component JAZBEHYOTPTENJ-JLNKQSITSA-N C20:5 omega-3 cis-5,8,11,14,17-EPA DSSTox_RID_79612 EPA;Timnodonic acid HMS1989C10 (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Icosapentaenoic acid 5,8,11,14,17-Eicosapentaenoate MFCD00065716 SR-01000946647 all-cis-icosa-5,8,11,14,17-pentaenoic acid AS-53730 CC-25864 cis-5,8,11,14,17-Eicosapentaenoic acid D08061 eicosapentaenoate FA 20:5 (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid HY-B0660 (all-Z)-delta5,8,11,14,17-Eicosapentaenoic acid IDI1_033798 5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)- (9CI) NCGC00161344-01 AAN7QOV9EA Timnodonic acid UNII-9B22238JYI component JAZBEHYOTPTENJ-JLNKQSITSA-N BSPBio_001328 CCRIS 3279 cis-5,8,11,14,17-Eicosapentaenoic acid, >=99% DSSTox_CID_21023 EPA HMS1361C10 (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid Icosapent [INN] 25377-48-4 L001256 5,8,11,14,17-Icosapentaenoate NCGC00161344-04 all-cis-5,8,11,14,17-eicosapentaenoic acid z,z,z,z,z-eicosa-5,8,11,14,17-pentaenoic acid C20:5n-3,6,9,12,15 CHEMBL460026 cis-Delta(5,8,11,14,17)-eicosapentaenoic acid DTXSID9041023 Eye Q HMS3402C10 (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid Icosapento 5,8,11,14,17-EICOSAPENTAENOIC ACID Miraxion 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoate SR-01000946647-1 all-cis-icosapentaenoate [ Show all ]
Inchi Key	JAZBEHYOTPTENJ-JLNKQSITSA-N
Inchi ID	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
PubChem CID	446284
ChEMBL	CHEMBL460026
IUPHAR	N/A
BindingDB	50242349
DrugBank	DB00159
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2000.0 nM	PMID24351031	BindingDB,ChEMBL
Ki	6000.0 nM	PMID12065583	BindingDB

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