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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Mus musculus (Mouse)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProt	Q62035
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3993
IUPHAR	334
DrugBank	N/A

Ligand

Name	CHEMBL351224
Molecular formula	C45H45ClN8O3S
IUPAC name	3-pyridin-3-ylpropyl 5-[(E)-[[3-[[9-(2-chlorophenyl)-3,7-dimethyl-17-thia-2,4,5,8,14-pentazatetracyclo[8.7.0.02,6.011,16]heptadeca-1(10),3,5,8,11(16)-pentaen-14-yl]methyl]phenyl]-pyridin-3-ylmethylidene]amino]oxypentanoate
Molecular weight	813.418
Hydrogen bond acceptor	11
Hydrogen bond donor	0
XlogP	7.7
Synonyms	3-(3-pyridyl)propyl 5-{[1-{3-[6-(2-chlorophenyl)-1,4-dimethyl-7,8,9,10-tetrahydro-4H-pyrido[4'',3'':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-9-ylmethyl]phenyl}-1-(3-pyridyl)-(E)-methylideneamino]-oxy}-pentanoate BDBM50110448
Inchi Key	IYXZHKJXXANYCY-XJKKGHOQSA-N
Inchi ID	InChI=1S/C45H45ClN8O3S/c1-30-44-51-50-31(2)54(44)45-41(43(49-30)36-16-3-4-17-38(36)46)37-19-22-53(29-39(37)58-45)28-33-11-7-14-34(25-33)42(35-15-9-21-48-27-35)52-57-24-6-5-18-40(55)56-23-10-13-32-12-8-20-47-26-32/h3-4,7-9,11-12,14-17,20-21,25-27,30H,5-6,10,13,18-19,22-24,28-29H2,1-2H3/b52-42+
PubChem CID	44377810
ChEMBL	CHEMBL351224
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<10.0 mg.kg-1	PMID11858999	ChEMBL
ED50	0.54 mg.kg-1	PMID11858999	ChEMBL

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