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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL399857
Molecular formula	C37H50N4O3S
IUPAC name	1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-[5-(3,5-dimethylphenyl)-4-[2-[3-methyl-4-(morpholine-4-carbonyl)piperidin-1-yl]ethyl]-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropan-1-one
Molecular weight	630.892
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	6.2
Synonyms	1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(3-methyl-4-(morpholine-4-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one BDBM50225096
Inchi Key	ATYOFXVORANGGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C37H50N4O3S/c1-23-18-24(2)20-26(19-23)33-30(11-13-39-12-10-29(25(3)22-39)35(42)40-14-16-44-17-15-40)31-21-32(45-34(31)38-33)37(4,5)36(43)41-27-6-7-28(41)9-8-27/h18-21,25,27-29,38H,6-17,22H2,1-5H3
PubChem CID	44444675
ChEMBL	CHEMBL399857
IUPHAR	N/A
BindingDB	50225096
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	43.0 nM	PMID17937987	BindingDB,ChEMBL

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