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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	5-Hydroxynicotinic acid
Molecular formula	C6H5NO3
IUPAC name	5-hydroxypyridine-3-carboxylic acid
Molecular weight	139.11
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.0
Synonyms	C-5668 EN300-73559 I02-0317 MCULE-4896018532 Oprea1_058796 3-Pyridinecarboxylic acid, 5-hydroxy- SBB010273 5-Hydroxynicotinic acid, 97% TPC-PY046 AB0006010 AE-848/00984004 BAS 01947666 CS-W009148 FT-0602367 KB-32240 MolPort-000-712-122 27828-71-3 PS-5446 5-22-05-00113 (Beilstein Handbook Reference) ST24033026 5-hydroxypyridine-3-carboxylicacid TRA0035387 AC-2839 AKOS005463460 BCP27371 BR-25698 DTXSID50182143 HC150102 LS-96574 NSC-606891 3-Hydroxypyridine-5-carboxylic acid RTR-012396 5-Hydroxy-nicotinic acid STK801985 5HN ACN-049106 ANW-26275 FC0319 J-400705 MFCD00129117 Oprea1_193943 3-Pyridinecarboxylic acid, 5-hydroxy- (9CI) SC-03080 5-hydroxynicotinicacid TR-012396 AB01334129-02 AK-25698 BBL010930 BDBM50391823 CTK1A2289 FT-0621168 KS-000006OW NCGC00342404-01 3-Carboxy-5-hydroxypyridine PubChem2415 5-hydroxy nicotinic acid ST50258394 5-hydroxypyridinium-3-carboxylate Z57124104 AC1L1QSR AM20051033 BRN 0115847 EBD49093 HMS1671H22 LS20727 NSC606891 3-pyridinecarboxylic acid, 5-hydroxy RW1130 SY003082 828H713 ACT02416 ATTDCVLRGFEHEO-UHFFFAOYSA-N CHEMBL2146902 FT-0084614 Jsp005378 MolPort-000-004-346 PB33816 3-PYRIDINECARBOXYLIC ACID,5-HYDROXY- SCHEMBL186161 5-hydroxypyridine-3-carboxylic acid TRA0020186 AB1001515 AKOS000272822 BC206883 BP-21442 DB-009085 H67204 KSC202E8T NICOTINIC ACID, 5-HYDROXY- 3-HYDROXY-5-PYRIDINECARBOXYLIC ACID RP01192 5-Hydroxy-3-pyridinecarboxylic acid STK531022 ZINC332673 ACMC-209gz9 AN-13577 [ Show all ]
Inchi Key	ATTDCVLRGFEHEO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10)
PubChem CID	34037
ChEMBL	CHEMBL2146902
IUPHAR	N/A
BindingDB	50391823
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	368000.0 nM	PMID24900524	BindingDB,ChEMBL

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