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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine
Molecular formula	C19H14N2O2
IUPAC name	4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine
Molecular weight	302.333
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.8
Synonyms	HMS2287A15 672925-50-7 BDBM41842 MLS000327159 CHEMBL1387472 SMR000179731 KS-00003A2B AC1MY3MU CHEBI:112905 MolPort-002-872-574 4-(2-methylphenoxy)-6-phenyl-furo[2,3-d]pyrimidine cid_3825639 ZINC6218639 5P-577S MCULE-2446178466 AKOS005093953 Oprea1_166637 [ Show all ]
Inchi Key	ATKPLDDGMIKJMB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14N2O2/c1-13-7-5-6-10-16(13)22-18-15-11-17(14-8-3-2-4-9-14)23-19(15)21-12-20-18/h2-12H,1H3
PubChem CID	3825639
ChEMBL	CHEMBL1387472
IUPHAR	N/A
BindingDB	41842
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	24325.0 nM	PubChem BioAssay data set	ChEMBL

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