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GLASS

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GPCR

Name	Metabotropic glutamate receptor 4
Species	Homo sapiens (Human)
Gene	GRM4
Synonym	mGluR4 mGlu4 receptor GPRC1D glutamate receptor
Disease	Anxiety disorder Neurological disease
Length	912
Amino acid sequence	MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProt	Q14833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T99402
ChEMBL	CHEMBL2736
IUPHAR	292
DrugBank	BE0000833

Ligand

Name	Ibotenic acid
Molecular formula	C5H6N2O4
IUPAC name	2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
Molecular weight	158.113
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.9
Synonyms	CAS_2552-55-8 D01YEN HMS3262C03 J-016035 MolPort-003-983-596 NCGC00261336-01 SMR001230640 31758-99-3 ACM2552558 amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid EU-0100651 HY-N2311 LP00651 NCGC00015555-05 (+/-)-Ibotenic acid NSC204850 2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid SR-01000075462-3 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo- alpha-amino-(3-hydroxy-5-isoxazolyl)acetic acid Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic acid C10600 CS-13243 GTPL1371 MLS002153141 NCGC00024524-03 (RS)-Ibotenic acid PDSP2_001410 2-amino-2-(3-oxoisoxazol-5-yl)acetic acid alpha-Amino-3-hydroxy-5-isoxazoleacetic acid CCG-204738 DL-Ibotenic acid HMS3266E19 L000672 NCGC00015555-03 ( inverted question mark)-alpha-Amino-3-hydroxy-5-isoxazoleacetic acid NSC 204850 SR-01000075462 4-Isoxazoline-5-acetic acid, .alpha.-amino-3-oxo- AKOS006228673 Amino(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid CHEMBL284895 FCH831700 I 2765 LS-86500 NCGC00015555-06 (+/-)alpha-amino-3-hydroxy-5-isoxazoleacetic acid NSC_1233 2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid ST50824671 5-Isoxazoleacetic acid,3-dihydro-3-oxo- alpha-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic acid BCP23586 C5H6N2O4 CTK8G0254 HMS2230A08 Ibotenic acid, ~95%, solid MolPort-003-941-798 NCGC00024524-04 (y)-Ibotenic acid SCHEMBL153359 2552-55-8 AC1L1B0Q Amanita muscaria CHEBI:5854 dl-ibotenic acid. HMS3369N13 Lopac0_000651 NCGC00015555-04 ( inverted question mark)-Ibotenic acid NSC-204850 2-amino-2-(3-hydroxy-1,2-oxazol-5-yl)acetic acid SR-01000075462-1 4-Isoxazoline-5-acetic acid, alpha-amino-3-oxo- AKOS027320609 Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid(Ibotenic acid) BDBM82355 CS-0020472 FT-0696850 Ibotenate MFCD00069294 NCGC00024524-02 (?)-Ibotenic acid PDSP1_001426 2-amino-2-(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid Tox21_500651 5-Isoxazoleacetic acid,a-amino-2,3-dihydro-3-oxo- alpha-amino-3-hydroxy-5-isooxazolacetic acid [ Show all ]
Inchi Key	IRJCBFDCFXCWGO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
PubChem CID	1233
ChEMBL	CHEMBL284895
IUPHAR	1371
BindingDB	82355
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID9873391	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9131252	BindingDB
Ki	<1000000.0 nM	PMID10893301	BindingDB,ChEMBL

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