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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1NU6H5
Molecular formula	C20H16N2O2
IUPAC name	[(E)-[phenyl(pyridin-2-yl)methylidene]amino] 2-methylbenzoate
Molecular weight	316.36
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.9
Synonyms	(2-methylphenyl)({[(E)-phenyl(pyridin-2-yl)methylidene]amino}oxy)methanone MolPort-002-207-334 AKOS001756318 ST4047645 MCULE-6637091362 A2047/0086104 phenyl(2-pyridinyl)methanone O-(2-methylbenzoyl)oxime STK710432 (1E)-2-phenyl-2-(2-pyridyl)-1-azavinyl 2-methylbenzoate MLS000573612 SMR000195401 CHEMBL3190740 [(E)-[phenyl(pyridin-2-yl)methylidene]amino] 2-methylbenzoate [ Show all ]
Inchi Key	IQFGCAZATSKXLR-ZBJSNUHESA-N
Inchi ID	InChI=1S/C20H16N2O2/c1-15-9-5-6-12-17(15)20(23)24-22-19(16-10-3-2-4-11-16)18-13-7-8-14-21-18/h2-14H,1H3/b22-19+
PubChem CID	5395535
ChEMBL	CHEMBL3190740
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	20233.0 nM	PubChem BioAssay data set	ChEMBL

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