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Name | Adenosine receptor A2b |
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Species | Mus musculus (Mouse) |
Gene | Adora2b |
Synonym | A2b A2B receptor A2BR adenosine receptor A2b |
Disease | N/A for non-human GPCRs |
Length | 332 |
Amino acid sequence | MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHGCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRMELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGQAGAQSTLSLGL |
UniProt | Q60614 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2237 |
IUPHAR | 20 |
DrugBank | N/A |
Name | 2-Cl-IB-Meca |
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Molecular formula | C18H18ClIN6O4 |
IUPAC name | (2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide |
Molecular weight | 544.734 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 4 |
XlogP | 1.9 |
Synonyms | AKOS022181265 CF 102 Cl-IB-MECA HMS2235L10 Namodenoson [USAN] [ Show all ] |
Inchi Key | IPSYPUKKXMNCNQ-PFHKOEEOSA-N |
Inchi ID | InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1 |
PubChem CID | 3035850 |
ChEMBL | CHEMBL431733 |
IUPHAR | 457 |
BindingDB | 21221 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 10000.0 nM | PMID18424135 | ChEMBL |
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