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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	4-amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Molecular formula	C8H8N4O2S2
IUPAC name	4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Molecular weight	256.298
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	0.5
Synonyms	4-amino-N-(1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide BDBM50034417 NSC35261 CHEMBL286737 AKOS000205626 NE45475 Benzenesulfonamide, 4-amino-N-1,3,4-thiadiazol-2-yl- SCHEMBL282714 AC1L5SXB MolPort-000-876-474 16806-29-4 ATEAASNFYTUARU-UHFFFAOYSA-N NSC-35261 4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide ZINC1667535 AC1Q6W3D N-(1,3,4-Thiadiazole-2-yl)-4-aminobenzenesulfonamide [ Show all ]
Inchi Key	ATEAASNFYTUARU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)
PubChem CID	234762
ChEMBL	CHEMBL286737
IUPHAR	N/A
BindingDB	50034417
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	57000.0 nM	PMID7731020	BindingDB,ChEMBL

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