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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	Pyronin Y
Molecular formula	C17H19ClN2O
IUPAC name	[6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium;chloride
Molecular weight	302.802
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	None
Synonyms	UNII-W659G165T1 [7-(dimethylamino)dibenzo[b,e]oxin-3-yl]dimethylamine, chloride 3,6-bis(dimethylamino)-xanthylium chloride AI3-52862 C11179 HY-D0971 Methyl pyronin NSC10454 Pyronin Y, for NA electrophoresis SBB080721 Xanthylium, 3,6-bis(dimethylamino)-, chloride (1:1) 6-(dimethylamino)-N,N-dimethylxanthen-3-iminium chloride AMMONIUM, (6-(DIMETHYLAMINO)-3H-XANTEN-3-YLIDENE)DIMETHYL-, CHLORIDE CHEMBL1486690 LS-17700 MolPort-001-795-077 Pyronin J Pyronin Yellow SMR001224393 Tetramethyl pyronin [6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium chloride 20195-95-3 AC1L1NZ1 BBC/419 EINECS 202-147-8 Methanaminium, N-(6-(dimethylamino)-3H-xanthen-3-ylidene)-N-methyl-, chloride NSC 10454 Pyronin Y, certified by the Biological Stain Commission, Dye content 50 % Pyronine Y W659G165T1 3,6-Bis(dimethylamino)xanthylium chloride AKOS005267240 CHEBI:8682 I14-50418 MFCD00011725 Pyronin Pyronin Y, pure, certified SCHEMBL1263862 [6-(dimethylamino)xanthen-3-ylidene]-dimethyl-ammonium 115624-92-5 61260-70-6 AN-24231 CS-7516 M869 N-(6-(Dimethylamino-3H-Xanthen-3-Ylidene)-N-Methyl-Methanaminium Chloride Pyronine ST080679 tetramethyldiaminoxanthylium chloride [6-(dimethylamino)xanthen-3-ylidene]dimethylamine, chloride 3,6-bis(dimethylamino)-10$l^{4}-xanthen-10-ylium chloride AC1Q1SCY C.I. 45005 HMS3020H13 Methanaminium, N-(6-(dimethylamino)-3H-xanthen-3-ylidene)-N-methyl-, chloride (9CI) NSC-10454 Pyronin Y, for microscopy (Bot., Fl., Hist.) Pyronine ZH Xanthylium, 3,6-bis(dimethylamino)-, chloride 6-(dimethylamino)-N,N-dimethyl-3H-xanthen-3-iminium chloride AKOS015916487 KS-0000471K MLS001359873 Pyronin G Pyronin Y, pure, high purity biological stain Schultz No. 853 [6-(dimethylamino)xanthen-3-ylidene]-dimethyl-ammonium chloride 167382-93-6 92-32-0 ARONIS24263 DTXSID8059051 MCULE-6105528808 N-[6-(dimethylamino)-3H-xanthen-3-ylidene]-N-methylmethanaminium chloride Pyronin Y (C.I. 45005) Pyronine G ST51006753 [ Show all ]
Inchi Key	INCIMLINXXICKS-UHFFFAOYSA-M
Inchi ID	InChI=1S/C17H19N2O.ClH/c1-18(2)14-7-5-12-9-13-6-8-15(19(3)4)11-17(13)20-16(12)10-14;/h5-11H,1-4H3;1H/q+1;/p-1
PubChem CID	7085
ChEMBL	CHEMBL1486690
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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