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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 2
Species	Homo sapiens (Human)
Gene	SSTR2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	Acromegaly Lung cancer Neuroendocrine cancer
Length	369
Amino acid sequence	MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30874
Protein Data Bank	N/A
GPCR-HGmod model	P30874
3D structure model	This predicted structure model is from GPCR-EXP P30874.
BioLiP	N/A
Therapeutic Target Database	T53024
ChEMBL	CHEMBL1804
IUPHAR	356
DrugBank	BE0003528

Ligand

Name	CHEMBL1077722
Molecular formula	C21H26N4O3
IUPAC name	N-[1-[(3-ethoxy-4-methoxyphenyl)methyl]piperidin-4-yl]-[1,3]oxazolo[5,4-c]pyridin-2-amine
Molecular weight	382.464
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.4
Synonyms	SCHEMBL1121263 ASUPXZZZUXUWIR-UHFFFAOYSA-N [1-(3-Ethoxy-4-methoxy-benzyl)-piperidin-4-yl]-oxazolo[5,4-c]pyridin-2-yl-amine BDBM50311355 N-(1-(3-ethoxy-4-methoxybenzyl)piperidin-4-yl)oxazolo[5,4-c]pyridin-2-amine
Inchi Key	ASUPXZZZUXUWIR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H26N4O3/c1-3-27-19-12-15(4-5-18(19)26-2)14-25-10-7-16(8-11-25)23-21-24-17-6-9-22-13-20(17)28-21/h4-6,9,12-13,16H,3,7-8,10-11,14H2,1-2H3,(H,23,24)
PubChem CID	46882666
ChEMBL	CHEMBL1077722
IUPHAR	N/A
BindingDB	50311355
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID19786348	PDSP,BindingDB,ChEMBL

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