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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Mu-type opioid receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRM1
Synonym	M-OR-1 MOR-1
Disease	N/A for non-human GPCRs
Length	98
Amino acid sequence	YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProt	P97266
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4354
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Hydromorphine
Molecular formula	C17H21NO3
IUPAC name	3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight	287.359
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.8
Synonyms	FT-0667072 Morphine, 7,8-dihydro- WLN: T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JQ P1 CAS_509-60-4 L000955 NSC117865 .alpha.-Dihydromorphine DIHYDROBROMORPHINE Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- Paramorphan AC1L6SLS Morphine, dihydro- (5.alpha.,6.alpha.)-4,5-Epoxy-17-methylmorphinan-3,6-diol Morphinan-3, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- NSC_273032 6.alpha.-Hydromorphol Dihydromorfin Morphinan-3,6.alpha.-diol, 4,5.alpha.-epoxy-17-methyl- SCHEMBL6123637 BDBM86518 IJVCSMSMFSCRME-UHFFFAOYSA-N NSC-117865 CHEMBL608541 Morphinan-3, 4,5.alpha.-epoxy-17-methyl- Paramorfan [ Show all ]
Inchi Key	IJVCSMSMFSCRME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3
PubChem CID	273032
ChEMBL	CHEMBL608541
IUPHAR	N/A
BindingDB	86518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.8 nM	PMID9686407	PDSP
Ki	1.94 nM	PMID6248635	PDSP
Ki	6.0 nM	PMID10585536	PDSP

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