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Name | 5-hydroxytryptamine receptor 7 |
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Species | Homo sapiens (Human) |
Gene | HTR7 |
Synonym | 5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 [ Show all ] |
Disease | Sleep disorders Schizophrenia Major depressive disorder |
Length | 479 |
Amino acid sequence | MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD |
UniProt | P34969 |
Protein Data Bank | N/A |
GPCR-HGmod model | P34969 |
3D structure model | This predicted structure model is from GPCR-EXP P34969. |
BioLiP | N/A |
Therapeutic Target Database | T79062 |
ChEMBL | CHEMBL3155 |
IUPHAR | 12 |
DrugBank | BE0000650, BE0004862 |
Name | Benzthiazole compound, 33p |
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Molecular formula | C21H23N3O3S |
IUPAC name | N-[1-[[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl]piperidin-4-yl]-2-hydroxyacetamide |
Molecular weight | 397.493 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 3.3 |
Synonyms | SCHEMBL4688910 N-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}piperidin-4-yl)-2-hydroxyacetamide BDBM24238 CHEMBL479383 N-{1-[4-(Benzothiazol-2-yloxy)-benzyl]-piperidin-4-yl}-2-hydroxy-acetamide [ Show all ] |
Inchi Key | IJHSPFFWIXGDBB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26) |
PubChem CID | 11200344 |
ChEMBL | CHEMBL479383 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | >10.0 % | PMID18588282 | ChEMBL |
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