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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	CHEMBL121744
Molecular formula	C24H27N3O2
IUPAC name	2-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,2,3,9-tetrahydrocarbazol-4-one
Molecular weight	389.499
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.7
Synonyms	BDBM50403682 2-[4-(2-Methoxyphenyl)piperazinomethyl]-1,2-dihydro-9H-carbazole-4(3H)-one
Inchi Key	IHQJQJGQVPNKSI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27N3O2/c1-29-23-9-5-4-8-21(23)27-12-10-26(11-13-27)16-17-14-20-24(22(28)15-17)18-6-2-3-7-19(18)25-20/h2-9,17,25H,10-16H2,1H3
PubChem CID	10715378
ChEMBL	CHEMBL121744
IUPHAR	N/A
BindingDB	50403682
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	316.23 nM	PMID9934473, PMID11754579	BindingDB,ChEMBL
Ki	630.96 nM	PMID9934473, PMID11754579	ChEMBL
Ki	631.0 nM	PMID9934473	BindingDB

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